Results From Largest Statin Study Of Patients With Alzheimer’s Disease Show Lipitor(R) Has No Significant Impact On Disease

clipped from www.medicalnewstoday.com In a study in patients with mild-to-moderate Alzheimer’s disease (AD), the addition of Lipitor (atorvastatin calcium tablets) 80 mg to Aricept® (donepezil HCl) 10 mg showed no significant differences in cognition or global function (key measures of Alzheimer’s progression) compared to placebo plus Aricept 10 mg. Furthermore, no statistically significant differences were seen on various cognitive, behavioral and functional secondary endpoints. However, the Lipitor arm was not associated with greater cognitive decline than the placebo arm in this trial. The results were presented today at the annual American Academy of Neurology meeting in Chicago. The 18-month study, called Lipitor’s Effect on Alzheimer’s Dementia (LEADe), included 640 patients and is the largest statin study in Alzheimer’s disease. http://www.aricept.com

 

Lovastatin Shown To Slow Progression Of Alzheimer’s Disease

This is a classic example of the Alzheimer’s CareGiver conundrum. I switched my mother from Lovastatin to Zocor after reading a similar article pointing out the benefits of statins.

I’ll put the article up on Zocor soon. Zocor did improve her cholesterol numbers.

clipped from www.medicalnewstoday.com High cholesterol levels are considered to be a risk factor for cardiovascular disease including stroke. Therefore, many cholesterol lowering drugs have been developed by pharmaceutical companies in recent years. One class of these drugs, statins, has been found to reduce the incidence of stroke and progression of Alzheimer’s disease when prophylactically administered. In a recent paper published in the Journal of Alzheimer’s Disease, Amalia Dolga and co-workers from the University of Groningen show that the statin lovastatin, in addition to lowering cholesterol, can also prevent nerve cells from dying in conditions that occur in Alzheimer’s disease Amalia Dolga found that statins stimulate nerve cells to produce a specific receptor molecule for a protein which plays a central role in the body’s immune response: Article adapted by Medical News Today from original press release.

 

Lovastatin Shown To Slow Progression Of Alzheimer’s Disease

This is a classic example of the Alzheimer’s CareGiver conundrum. I switched my mother from Lovastatin to Zocor after reading a similar article pointing out the benefits of statins.

I’ll put the article up on Zocor soon. Zocor did improve her cholesterol numbers.

clipped from www.medicalnewstoday.com High cholesterol levels are considered to be a risk factor for cardiovascular disease including stroke. Therefore, many cholesterol lowering drugs have been developed by pharmaceutical companies in recent years. One class of these drugs, statins, has been found to reduce the incidence of stroke and progression of Alzheimer’s disease when prophylactically administered. In a recent paper published in the Journal of Alzheimer’s Disease, Amalia Dolga and co-workers from the University of Groningen show that the statin lovastatin, in addition to lowering cholesterol, can also prevent nerve cells from dying in conditions that occur in Alzheimer’s disease Amalia Dolga found that statins stimulate nerve cells to produce a specific receptor molecule for a protein which plays a central role in the body’s immune response: Article adapted by Medical News Today from original press release.